Leukemia inhibitory factor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	cytokine
gptkbp:abbreviation	gptkb:LIF
gptkbp:alternativeName	gptkb:D_factor gptkb:HILDA melanoma-derived LIF cholinergic differentiation factor
gptkbp:category	growth factor cytokine
gptkbp:discoveredBy	1988
gptkbp:effect	modulates immune response affects neural cell differentiation induces acute phase response influences bone metabolism promotes self-renewal of mouse embryonic stem cells
gptkbp:encodedBy	gptkb:LIF_gene
gptkbp:Entrez_Gene_ID	3976 ENSG00000104856
gptkbp:expressedIn	gptkb:cancer gptkb:kidney gptkb:placenta gptkb:testis liver bone marrow
gptkbp:function	regulation of cell differentiation maintenance of embryonic stem cell pluripotency inhibition of differentiation in myeloid leukemic cells
gptkbp:HGNC_ID	6596
https://www.w3.org/2000/01/rdf-schema#label	Leukemia inhibitory factor
gptkbp:locatedOnChromosome	22q12.2
gptkbp:medicalUse	potential cancer therapy potential infertility treatment
gptkbp:molecularWeight	~20 kDa
gptkbp:OMIM	159540
gptkbp:orthologIn	gptkb:bovine_LIF gptkb:mouse_LIF gptkb:rat_LIF gptkb:human_LIF
gptkbp:recipient	gptkb:LIF_receptor
gptkbp:relatedTo	gptkb:interleukin-6_family
gptkbp:species	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:structure	gptkb:protein
gptkbp:type	gptkb:MAPK_pathway gptkb:JAK/STAT_pathway
gptkbp:UniProtID	gptkb:P15018
gptkbp:usedIn	stem cell culture
gptkbp:bfsParent	gptkb:LIF_gene
gptkbp:bfsLayer	8