Leukemia Inhibitory Factor (LIF)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein cytokine
gptkbp:alias	gptkb:D_factor gptkb:HILDA gptkb:EMI gptkb:LIF CDF MLPLI
gptkbp:discoveredBy	1988
gptkbp:encodedBy	gptkb:LIF_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000128313 3976 GCID:LIF
gptkbp:expressedIn	gptkb:cancer gptkb:placenta liver bone marrow uterus
gptkbp:function	involved in inflammation regulates cell differentiation inhibits differentiation of embryonic stem cells involved in neural development induces differentiation in myeloid leukemic cells involved in bone metabolism
gptkbp:gene	gptkb:LIF
gptkbp:HGNC_ID	6596
https://www.w3.org/2000/01/rdf-schema#label	Leukemia Inhibitory Factor (LIF)
gptkbp:locatedOnChromosome	22q12.2
gptkbp:member	gptkb:interleukin-6_family
gptkbp:molecularWeight	~20 kDa
gptkbp:OMIM	159540
gptkbp:pathway	gptkb:MAPK_pathway gptkb:JAK/STAT_pathway
gptkbp:PDB	gptkb:1EMR
gptkbp:producedBy	gptkb:T_cells macrophages fibroblasts
gptkbp:recipient	gptkb:gp130 gptkb:LIF_receptor_(LIFR)
gptkbp:significance	implicated in cancer implicated in neurodegenerative diseases implicated in infertility implicated in inflammatory diseases
gptkbp:species	gptkb:human gptkb:mouse right
gptkbp:structure	gptkb:protein
gptkbp:UniProtID	gptkb:P15018
gptkbp:used_in	stem cell culture
gptkbp:used_to_maintain	pluripotency in mouse embryonic stem cells
gptkbp:bfsParent	gptkb:LIFR
gptkbp:bfsLayer	8