|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:LDH-A
gptkb:LDH_muscle_subunit
Cellular lactate dehydrogenase A
|
|
gptkbp:associatedWith
|
gptkb:LDHA_deficiency
|
|
gptkbp:cofactor
|
NAD+
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000134333
3939
|
|
gptkbp:enzymeCommissionNumber
|
1.1.1.27
|
|
gptkbp:expressedIn
|
Expressed in heart
Expressed in liver
Highly expressed in skeletal muscle
|
|
gptkbp:fullName
|
gptkb:L-lactate_dehydrogenase_A_chain
|
|
gptkbp:function
|
Catalyzes the conversion of L-lactate and NAD to pyruvate and NADH
|
|
gptkbp:gene
|
gptkb:LDHA
|
|
gptkbp:geneOntologyBiologicalProcess
|
glycolytic process
|
|
gptkbp:geneOntologyCellularComponent
|
gptkb:cytoplasm
|
|
gptkbp:geneOntologyMolecularFunction
|
L-lactate dehydrogenase activity
|
|
gptkbp:hasIsoform
|
LDHA-1
LDHA-2
|
|
gptkbp:HGNC_ID
|
HGNC:6541
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LDHA HUMAN
|
|
gptkbp:interactsWith
|
gptkb:NADH
gptkb:Pyruvate
L-lactate
|
|
gptkbp:length
|
332 amino acids
|
|
gptkbp:locatedOnChromosome
|
11p15.4
|
|
gptkbp:molecularWeight
|
36 kDa
|
|
gptkbp:mutationAssociatedWith
|
Deficiency causes exertional myoglobinuria
|
|
gptkbp:OMIM
|
150000
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
LDHA_MOUSE
LDHA_RAT
|
|
gptkbp:pathway
|
gptkb:Glycolysis
Pyruvate metabolism
|
|
gptkbp:PDB
|
gptkb:1LLD
gptkb:4AJP
1I10
|
|
gptkbp:postTranslationalModification
|
Phosphorylation
Acetylation
Ubiquitination
|
|
gptkbp:proteinFamily
|
LDH family
LDH/MDH superfamily
|
|
gptkbp:referenceGenome
|
gptkb:NP_005557.1
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:sequenceStatus
|
Complete
|
|
gptkbp:structure
|
Tetramer
|
|
gptkbp:subcellularLocation
|
gptkb:Cytoplasm
|
|
gptkbp:tissue_specificity
|
gptkb:Heart
Liver
Muscle
|
|
gptkbp:UniProtID
|
gptkb:P00338
|
|
gptkbp:bfsParent
|
gptkb:P00338_(human_LDHA)
|
|
gptkbp:bfsLayer
|
7
|