L-lactate dehydrogenase A chain

URI: https://gptkb.org/entity/L-lactate_dehydrogenase_A_chain
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:LDH-A
muscle-type lactate dehydrogenase
gptkbp:alternativeSplicing yes
gptkbp:associatedWith gptkb:anemia
myoglobinuria
gptkbp:cofactor NAD+
gptkbp:encodedBy gptkb:LDHA_gene
gptkbp:Entrez_Gene_ID 3939
gptkbp:enzymeCommissionNumber 1.1.1.27
gptkbp:expressedIn gptkb:skeletal_muscle
gptkb:kidney
gptkb:testis
liver
red blood cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function catalyzes conversion of pyruvate to lactate
NADH-dependent oxidoreductase
gptkbp:gene gptkb:LDHA
https://www.w3.org/2000/01/rdf-schema#label L-lactate dehydrogenase A chain
gptkbp:inhibitedBy gptkb:oxamate
gptkb:FX11
gossypol
gptkbp:involves glycolysis
anaerobic metabolism
gptkbp:KEGGID gptkb:hsa:3939
gptkbp:locatedOnChromosome chromosome 11p15.4
gptkbp:location gptkb:cytoplasm
gptkbp:molecularWeight 36 kDa
gptkbp:mutationAssociatedWith gptkb:LDHA_deficiency
gptkbp:OMIM 150000
gptkbp:orthologInMouse gptkb:Ldha
gptkbp:orthologInZebrafish ldha
gptkbp:PDB 1I10
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:product lactate
NAD+
gptkbp:Reactome gptkb:R-HSA-70263
gptkbp:RefSeq gptkb:NP_005557.1
gptkbp:significance elevated in some cancers
marker for tissue damage
gptkbp:structure homotetramer or heterotetramer with LDHB
gptkbp:substrate gptkb:pyruvate
gptkbp:subunit lactate dehydrogenase tetramer
gptkbp:UniProtID gptkb:P00338
gptkbp:bfsParent gptkb:1I10_(human_LDHA)
gptkb:P00338_(human_LDHA)
gptkbp:bfsLayer 7