|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:LDH-M
GSD11
LDH muscle
|
|
gptkbp:alternativeName
|
gptkb:LDH-A
gptkb:LDH_muscle_subunit
GSD11
|
|
gptkbp:associatedWith
|
gptkb:LDHA_deficiency
glycogen storage disease XI
|
|
gptkbp:biologicalProcess
|
response to hypoxia
carbohydrate metabolic process
lactate dehydrogenase activity
|
|
gptkbp:clinicalTrialPhase
|
LDH isoenzyme analysis
|
|
gptkbp:discoveredBy
|
biochemical studies
|
|
gptkbp:encodes
|
gptkb:lactate_dehydrogenase_A
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000134333
3939
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
gptkb:testis
liver
|
|
gptkbp:firstDescribed
|
1960s
|
|
gptkbp:fullName
|
lactate dehydrogenase A gene
|
|
gptkbp:function
|
catalyzes conversion of pyruvate to lactate
involved in anaerobic glycolysis
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:6541
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LDHA gene
|
|
gptkbp:length
|
7 exons
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
11p15.4
|
|
gptkbp:mutationAssociatedWith
|
causes exertional myoglobinuria
causes hemolytic anemia
|
|
gptkbp:OMIM
|
150000
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Ldha gene
rat Ldha gene
|
|
gptkbp:pathway
|
gptkb:pyruvate_metabolism
glycolysis
|
|
gptkbp:product
|
tetramer
NP_005557
homotetramer or heterotetramer with LDHB
|
|
gptkbp:proteinFamily
|
gptkb:lactate/malate_dehydrogenase_family
|
|
gptkbp:referenceGenome
|
NM_005566
|
|
gptkbp:regulates
|
regulated by HIF-1
upregulated in hypoxia
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P00338
|
|
gptkbp:bfsParent
|
gptkb:LDH-A
|
|
gptkbp:bfsLayer
|
7
|