Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alsoKnownAs |
gptkb:KRAS
|
| gptkbp:associatedWith |
gptkb:cancer
colorectal cancer pancreatic cancer |
| gptkbp:discoveredBy |
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop |
| gptkbp:encodes |
gptkb:KRAS_protein
|
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000133703
3845 |
| gptkbp:expressedIn |
many tissues
|
| gptkbp:firstDescribed |
1982
|
| gptkbp:function |
guanine nucleotide exchange factor
|
| gptkbp:HGNC_ID |
6407
|
| https://www.w3.org/2000/01/rdf-schema#label |
Ki-Ras
|
| gptkbp:locatedOnChromosome |
12p12.1
|
| gptkbp:memberOf |
gptkb:RAS_gene_family
|
| gptkbp:mutationAssociatedWith |
oncogenic
|
| gptkbp:mutationCommonIn |
adenocarcinomas
|
| gptkbp:OMIM |
190070
|
| gptkbp:orthologInMouse |
gptkb:Kras
|
| gptkbp:pathway |
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway |
| gptkbp:proteinFamily |
small molecule
|
| gptkbp:regulates |
cell differentiation
cell proliferation cell survival |
| gptkbp:target |
anticancer drugs
|
| gptkbp:UniProtID |
gptkb:P01116
|
| gptkbp:bfsParent |
gptkb:KRAS_protein
|
| gptkbp:bfsLayer |
6
|