|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
recurrent bacterial infections
autosomal recessive IRAK4 deficiency
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodedBy
|
IRAK4 gene
|
|
gptkbp:ensembl
|
gptkb:ENSG00000198001
|
|
gptkbp:Entrez_Gene_ID
|
51135
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.1
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:thymus
liver
spleen
immune cells
|
|
gptkbp:fullName
|
Interleukin-1 receptor-associated kinase 4
|
|
gptkbp:function
|
serine/threonine-protein kinase
mediates signal transduction of interleukin-1 receptors
mediates signal transduction of Toll-like receptors
|
|
gptkbp:gene
|
gptkb:IRAK4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IRAK4
|
|
gptkbp:interactsWith
|
gptkb:Toll-like_receptors
gptkb:TRAF6
IRAK1
interleukin-1 receptor
MyD88
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
gptkb:NF-kappaB_signaling_pathway
innate immune response
|
|
gptkbp:involves
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
|
|
gptkbp:locatedOnChromosome
|
12q12
|
|
gptkbp:molecularWeight
|
52 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2NRU
|
|
gptkbp:phosphorylates
|
IRAK1
MyD88
|
|
gptkbp:RefSeq
|
NM_016123
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
|
|
gptkbp:structureType
|
kinase domain
death domain
|
|
gptkbp:target
|
CA-4948
IRAK4 inhibitors
PF-06650833
|
|
gptkbp:UniProtID
|
Q9NWZ3
|
|
gptkbp:bfsParent
|
gptkb:KT-474
gptkb:Toll-like_receptor_signaling_pathway
gptkb:TLR8
|
|
gptkbp:bfsLayer
|
8
|