Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:cofactor |
zinc
|
| gptkbp:enzymeCommissionNumber |
EC 3.5.2.6
|
| gptkbp:firstDescribed |
gptkb:Japan
1991 |
| gptkbp:foundIn |
gptkb:Enterobacteriaceae
gptkb:Pseudomonas_aeruginosa gptkb:Acinetobacter_baumannii |
| gptkbp:fullName |
gptkb:Imipenemase-1
|
| gptkbp:function |
hydrolyzes beta-lactam antibiotics
|
| gptkbp:gene |
gptkb:blaIMP-1
|
| https://www.w3.org/2000/01/rdf-schema#label |
IMP-I
|
| gptkbp:inhibitedBy |
gptkb:clavulanic_acid
gptkb:sulbactam gptkb:EDTA tazobactam |
| gptkbp:mechanismOfAction |
metallo-beta-lactamase
|
| gptkbp:proteinFamily |
gptkb:IMP-type_metallo-beta-lactamases
|
| gptkbp:relatedTo |
gptkb:NDM-type_metallo-beta-lactamases
gptkb:VIM-type_metallo-beta-lactamases |
| gptkbp:resistantTo |
gptkb:cephalosporins
gptkb:monobactams penicillins carbapenem antibiotics |
| gptkbp:significance |
major cause of antibiotic resistance in hospitals
|
| gptkbp:transmission |
plasmid-mediated
|
| gptkbp:bfsParent |
gptkb:Explorer_106
|
| gptkbp:bfsLayer |
6
|