IMP-type metallo-beta-lactamases
GPTKB entity
Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
metallo-beta-lactamase |
| gptkbp:alternativeName |
Imipenemase
|
| gptkbp:catalyzes |
hydrolysis of beta-lactam antibiotics
|
| gptkbp:cofactor |
zinc
|
| gptkbp:confers_resistance_to |
carbapenem antibiotics
|
| gptkbp:encodedBy |
blaIMP gene
|
| gptkbp:first_identified_in |
gptkb:Japan
|
| gptkbp:firstDescribed |
1991
|
| gptkbp:foundIn |
gptkb:Enterobacteriaceae
gptkb:Pseudomonas_aeruginosa gptkb:Acinetobacter_baumannii |
| https://www.w3.org/2000/01/rdf-schema#label |
IMP-type metallo-beta-lactamases
|
| gptkbp:inhibitedBy |
gptkb:EDTA
|
| gptkbp:mechanismOfAction |
breaks beta-lactam ring
|
| gptkbp:not_inhibited_by |
gptkb:clavulanic_acid
gptkb:sulbactam tazobactam |
| gptkbp:resistance_mechanism |
antibiotic hydrolysis
|
| gptkbp:significance |
multidrug resistance
|
| gptkbp:spreadTo |
plasmids
|
| gptkbp:subclassOf |
class B beta-lactamases
|
| gptkbp:bfsParent |
gptkb:IMP-I
|
| gptkbp:bfsLayer |
7
|