Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:alternativeName |
gptkb:mast_cell_growth_factor
multi-colony stimulating factor |
| gptkbp:associatedWith |
leukemia
allergic inflammation hematopoiesis |
| gptkbp:discoveredIn |
1980s
|
| gptkbp:encodedBy |
IL3 gene
|
| gptkbp:Entrez_Gene_ID |
3562
ENSG00000164399 |
| gptkbp:fullName |
Interleukin 3
|
| gptkbp:function |
stimulates growth and differentiation of hematopoietic cells
promotes proliferation of multipotent hematopoietic stem cells supports survival of myeloid progenitors |
| gptkbp:gene |
gptkb:IL3
|
| https://www.w3.org/2000/01/rdf-schema#label |
IL3
|
| gptkbp:involvedIn |
immune response
allergic response inflammatory response |
| gptkbp:locatedOnChromosome |
5q31.1
|
| gptkbp:molecularWeight |
15-20 kDa
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Rattus_norvegicus |
| gptkbp:producedBy |
gptkb:T_cells
gptkb:mast_cells gptkb:eosinophils monocytes |
| gptkbp:promotion |
differentiation of hematopoietic cells
colony formation in bone marrow proliferation of hematopoietic stem cells survival of hematopoietic progenitors |
| gptkbp:receptorSubunit |
CSF2RB (beta subunit)
IL3RA (alpha subunit) |
| gptkbp:recipient |
IL3 receptor
|
| gptkbp:regulates |
myeloid progenitor cells
dendritic cell function erythroid progenitor cells basophil function eosinophil function granulocyte progenitor cells lymphoid progenitor cells macrophage function mast cell progenitor cells megakaryocyte function monocyte progenitor cells |
| gptkbp:relatedTo |
gptkb:IL5
gptkb:GM-CSF |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
gptkb:protein
|
| gptkbp:UniProtID |
P08700
|
| gptkbp:bfsParent |
gptkb:RUNX1
|
| gptkbp:bfsLayer |
7
|