|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
cardiac hypertrophy
|
|
gptkbp:component
|
gptkb:nucleus
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:encodedBy
|
gptkb:HDAC5_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:HDAC5
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.5.1.98
|
|
gptkbp:exportedFromNucleusBy
|
gptkb:14-3-3_proteins
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
liver
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_5
|
|
gptkbp:function
|
histone deacetylase activity
histone deacetylation
transcriptional repression
|
|
gptkbp:GOProcess
|
chromatin modification
|
|
gptkbp:HGNC_ID
|
HGNC:14065
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hdac5
|
|
gptkbp:inhibitedBy
|
gptkb:valproic_acid
gptkb:sodium_butyrate
gptkb:trichostatin_A
|
|
gptkbp:interactsWith
|
gptkb:HDAC3
MEF2
|
|
gptkbp:locatedOnChromosome
|
17q21.31
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:class_IIa_histone_deacetylases
|
|
gptkbp:molecularWeight
|
~112 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4CBY
|
|
gptkbp:phosphorylates
|
gptkb:CaMK
protein kinase D
|
|
gptkbp:RefSeq
|
NM_005474
|
|
gptkbp:regulates
|
gene expression
regulated by phosphorylation
|
|
gptkbp:relatedTo
|
cell differentiation
neuronal development
epigenetic regulation
stress response
muscle development
memory formation
|
|
gptkbp:UniProtID
|
gptkb:Q9UQL6
|
|
gptkbp:bfsParent
|
gptkb:HDAC5
|
|
gptkbp:bfsLayer
|
8
|