|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
5-HT1B
serotonin receptor 1B
|
|
gptkbp:associatedWith
|
G protein-coupled receptor signaling pathway
neurotransmitter receptor activity
serotonin receptor activity
|
|
gptkbp:discoveredBy
|
Lesch et al.
|
|
gptkbp:encodes
|
gptkb:5-hydroxytryptamine_receptor_1B
|
|
gptkbp:Entrez_Gene_ID
|
3351
ENSG00000169760
|
|
gptkbp:expressedIn
|
brain
central nervous system
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:foundIn
|
gptkb:plasma_membrane
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
rs11568817
rs130058
rs6296
rs6297
rs6298
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HTR1B
|
|
gptkbp:involvedIn
|
regulation of neurotransmitter release
modulation of synaptic transmission
behavioral response to serotonin
|
|
gptkbp:ligand
|
serotonin
|
|
gptkbp:locatedOnChromosome
|
6q13
|
|
gptkbp:mutationAssociatedWith
|
gptkb:depression
aggressive behavior
substance abuse
psychiatric disorders
|
|
gptkbp:OMIM
|
182131
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Htr1b
|
|
gptkbp:proteinFamily
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:regulates
|
dopamine release
GABA release
acetylcholine release
serotonin release
|
|
gptkbp:targetOfDrug
|
gptkb:triptans
gptkb:naratriptan
gptkb:zolmitriptan
gptkb:ergotamine
propranolol
sumatriptan
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P28222
|
|
gptkbp:bfsParent
|
gptkb:DB01216
|
|
gptkbp:bfsLayer
|
7
|