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ergotamine
URI:
https://gptkb.org/entity/ergotamine
GPTKB entity
Statements (46)
Predicate
Object
gptkbp:instanceOf
gptkb:drug
alkaloid
gptkbp:administeredBy
oral
sublingual
rectal
gptkbp:affiliatedWith
gptkb:ergot_alkaloids
gptkbp:ATCCode
N02CA02
gptkbp:CASNumber
113-15-5
gptkbp:chemicalFormula
C33H35N5O5
gptkbp:contraindication
pregnancy
coronary artery disease
peripheral vascular disease
gptkbp:derivedFrom
gptkb:ergot_fungus
gptkbp:discoveredBy
gptkb:Arthur_Stoll
gptkbp:discoveredIn
1918
gptkbp:eliminationHalfLife
2 hours
gptkbp:excretion
urine
bile
https://www.w3.org/2000/01/rdf-schema#label
ergotamine
gptkbp:interactsWith
gptkb:triptans
gptkb:macrolide_antibiotics
protease inhibitors
gptkbp:IUPACName
(6aR,9R)-N-[(2S,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-2,3,4,5,6,10a-hexahydro-1H-oxazolo[3,2-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-yl]-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
gptkbp:legalStatus
prescription only
gptkbp:mechanismOfAction
serotonin receptor agonist
gptkbp:meltingPoint
210–215 °C
gptkbp:metabolism
liver
gptkbp:molecularWeight
581.67 g/mol
gptkbp:pregnancyCategory
gptkb:X_(US)
gptkbp:PubChem_CID
7922
8223
DB00696
CHEMBL1200698
gptkbp:riskOfOverdose
ergotism
gptkbp:routeOfAdministration
oral
sublingual
rectal
gptkbp:sideEffect
nausea
vomiting
vasoconstriction
gptkbp:UNII
PR834QJZ4P
gptkbp:usedFor
treatment of migraine
treatment of cluster headaches
gptkbp:WHOModelListOfEssentialMedicines
yes
gptkbp:bfsParent
gptkb:Erythromycin
gptkbp:bfsLayer
5