ergotamine

GPTKB entity

Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:drug
alkaloid
gptkbp:administeredBy oral
sublingual
rectal
gptkbp:affiliatedWith gptkb:ergot_alkaloids
gptkbp:ATCCode N02CA02
gptkbp:CASNumber 113-15-5
gptkbp:chemicalFormula C33H35N5O5
gptkbp:contraindication pregnancy
coronary artery disease
peripheral vascular disease
gptkbp:derivedFrom gptkb:ergot_fungus
gptkbp:discoveredBy gptkb:Arthur_Stoll
gptkbp:discoveredIn 1918
gptkbp:eliminationHalfLife 2 hours
gptkbp:excretion urine
bile
https://www.w3.org/2000/01/rdf-schema#label ergotamine
gptkbp:interactsWith gptkb:triptans
gptkb:macrolide_antibiotics
protease inhibitors
gptkbp:IUPACName (6aR,9R)-N-[(2S,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-2,3,4,5,6,10a-hexahydro-1H-oxazolo[3,2-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-yl]-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction serotonin receptor agonist
gptkbp:meltingPoint 210–215 °C
gptkbp:metabolism liver
gptkbp:molecularWeight 581.67 g/mol
gptkbp:pregnancyCategory gptkb:X_(US)
gptkbp:PubChem_CID 7922
8223
DB00696
CHEMBL1200698
gptkbp:riskOfOverdose ergotism
gptkbp:routeOfAdministration oral
sublingual
rectal
gptkbp:sideEffect nausea
vomiting
vasoconstriction
gptkbp:UNII PR834QJZ4P
gptkbp:usedFor treatment of migraine
treatment of cluster headaches
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Erythromycin
gptkbp:bfsLayer 5