|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:serotonin_receptor_1A
5-HT1A
|
|
gptkbp:associatedWith
|
gptkb:depression
anxiety
mood regulation
serotonin signaling
|
|
gptkbp:discoveredBy
|
Langer SZ
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodes
|
gptkb:5-HT1A_receptor
|
|
gptkbp:Entrez_Gene_ID
|
3350
ENSG00000178394
|
|
gptkbp:expressedIn
|
gptkb:cerebral_cortex
brain
hippocampus
|
|
gptkbp:function
|
inhibition of neuronal firing
modulation of serotoninergic neurotransmission
regulation of mood and anxiety
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
5292
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HTR1A gene
|
|
gptkbp:ligand
|
serotonin
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5q12.3
|
|
gptkbp:mutationAssociatedWith
|
gptkb:major_depressive_disorder
schizophrenia
anxiety disorders
psychiatric disorders
|
|
gptkbp:OMIM
|
182135
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:pathway
|
neuroactive ligand-receptor interaction
serotonergic synapse
GPCR signaling pathway
|
|
gptkbp:product
|
5-hydroxytryptamine receptor 1A
|
|
gptkbp:recipient
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:referenceGenome
|
NM_000524
|
|
gptkbp:regulates
|
neurotransmitter release
adenylate cyclase activity
neuronal excitability
|
|
gptkbp:target
|
gptkb:8-OH-DPAT
gptkb:WAY-100635
gptkb:buspirone
antidepressants
anxiolytics
|
|
gptkbp:UniProtID
|
gptkb:P08908
|
|
gptkbp:bfsParent
|
gptkb:5-HT1_receptor
|
|
gptkbp:bfsLayer
|
7
|