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gptkbp:instanceOf
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UniProt accession number
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gptkbp:alternativeName
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gptkb:B2AR
Beta-2 adrenoceptor
Beta-2 AR
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gptkbp:associatedWith
|
Heart failure
Obesity
Asthma
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gptkbp:citation
|
ChEMBL: CHEMBL210
DrugBank: DB00871
Ensembl: ENSG00000169252
GeneID: 154
HGNC: 286
OMIM: 109690
PDB: 2RH1
Reactome: R-HSA-390696
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gptkbp:firstDescribed
|
1986
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gptkbp:function
|
gptkb:G_protein-coupled_receptor
Adrenergic receptor activity
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gptkbp:gene
|
gptkb:ADRB2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P08908
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gptkbp:length
|
413 amino acids
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gptkbp:ligand
|
gptkb:Norepinephrine
Epinephrine
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gptkbp:locatedOnChromosome
|
5
|
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gptkbp:location
|
5q31-q32
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gptkbp:molecularWeight
|
46 kDa
|
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gptkbp:mutationAssociatedWith
|
gptkb:Gln27Glu
gptkb:Thr164Ile
Gly16Arg
|
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gptkbp:name
|
ADR2B_HUMAN
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:pathway
|
gptkb:cAMP_signaling_pathway
|
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gptkbp:postTranslationalModification
|
Phosphorylation
Glycosylation
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gptkbp:refersTo
|
Beta-2 adrenergic receptor
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gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
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gptkbp:sequenceStatus
|
Reviewed
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gptkbp:species
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gptkb:human
|
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gptkbp:structure
|
7 transmembrane domains
|
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gptkbp:subcellularLocation
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gptkb:Cell_membrane
|
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gptkbp:targetOfDrug
|
Beta-agonists
Beta-blockers
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gptkbp:tissue_specificity
|
gptkb:Heart
gptkb:Uterus
Liver
Lung
Vascular smooth muscle
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gptkbp:type
|
G protein signaling
Adenylate cyclase activation
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gptkbp:bfsParent
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gptkb:serotonin_receptor_1A
gptkb:5-HT1A_receptor
gptkb:HTR1A_gene
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gptkbp:bfsLayer
|
8
|