|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeName
|
5-hydroxytryptamine receptor 1A
serotonin 1A receptor
|
|
gptkbp:associatedWith
|
gptkb:depression
schizophrenia
anxiety disorders
suicide risk
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:effect
|
opens potassium channels
decreases cAMP
hyperpolarizes neurons
|
|
gptkbp:encodedBy
|
gptkb:HTR1A_gene
|
|
gptkbp:enemyOf
|
gptkb:8-OH-DPAT
gptkb:WAY-100635
gptkb:pindolol
gptkb:buspirone
flesinoxan
spiperone
|
|
gptkbp:foundIn
|
mammals
|
|
gptkbp:function
|
regulation of mood
inhibitory neurotransmission
regulation of sleep
regulation of anxiety
|
|
gptkbp:ligand
|
serotonin
|
|
gptkbp:locatedIn
|
gptkb:human
gptkb:cortex
gptkb:raphe_nuclei
brain
hippocampus
|
|
gptkbp:locatedOnChromosome
|
5q12.3
|
|
gptkbp:targetOfDrug
|
antidepressants
anxiolytics
|
|
gptkbp:type
|
Gi/o protein
|
|
gptkbp:UniProtID
|
gptkb:P08908
|
|
gptkbp:bfsParent
|
gptkb:Cannabidiol
gptkb:serotonin_receptor_1A
gptkb:rhodopsin-like_GPCR_family
gptkb:N,N-Dimethyltryptamine
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
5-HT1A receptor
|