Statements (38)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:receptor_tyrosine_kinase
gptkb:G_protein-coupled_receptor |
| gptkbp:alternativeName |
5-hydroxytryptamine receptor 1A
serotonin 1A receptor |
| gptkbp:associatedWith |
gptkb:depression
schizophrenia anxiety disorders suicide risk |
| gptkbp:discoveredIn |
1980s
|
| gptkbp:effect |
opens potassium channels
decreases cAMP hyperpolarizes neurons |
| gptkbp:encodedBy |
gptkb:HTR1A_gene
|
| gptkbp:enemyOf |
gptkb:8-OH-DPAT
gptkb:WAY-100635 gptkb:pindolol gptkb:buspirone flesinoxan spiperone |
| gptkbp:foundIn |
mammals
|
| gptkbp:function |
regulation of mood
inhibitory neurotransmission regulation of sleep regulation of anxiety |
| https://www.w3.org/2000/01/rdf-schema#label |
5-HT1A receptor
|
| gptkbp:ligand |
serotonin
|
| gptkbp:locatedIn |
gptkb:human
gptkb:cortex gptkb:raphe_nuclei brain hippocampus |
| gptkbp:locatedOnChromosome |
5q12.3
|
| gptkbp:targetOfDrug |
antidepressants
anxiolytics |
| gptkbp:type |
Gi/o protein
|
| gptkbp:UniProtID |
gptkb:P08908
|
| gptkbp:bfsParent |
gptkb:5-HT1_receptor
|
| gptkbp:bfsLayer |
7
|