|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeName
|
gptkb:5-HT1A_receptor
|
|
gptkbp:binds
|
serotonin
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:DrugTargetFor
|
antipsychotics
antidepressants
anxiolytics
|
|
gptkbp:encodedBy
|
gptkb:HTR1A_gene
|
|
gptkbp:enemyOf
|
gptkb:8-OH-DPAT
gptkb:WAY-100635
gptkb:pindolol
gptkb:buspirone
|
|
gptkbp:Entrez_Gene_ID
|
3350
|
|
gptkbp:expressedIn
|
gptkb:cortex
gptkb:raphe_nuclei
brain
hippocampus
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:function
|
regulation of mood
inhibitory neurotransmission
regulation of appetite
regulation of sleep
regulation of anxiety
|
|
gptkbp:HGNC_ID
|
5292
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
serotonin receptor 1A
|
|
gptkbp:IUPHAR_ID
|
1
|
|
gptkbp:locatedOnChromosome
|
5q12.3
|
|
gptkbp:membraneLocation
|
gptkb:cell_membrane
|
|
gptkbp:OMIM
|
182135
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:postSynaptic
|
yes
|
|
gptkbp:preSynaptic
|
yes
|
|
gptkbp:regulates
|
dopamine release
cortisol secretion
serotonin release
|
|
gptkbp:relatedTo
|
gptkb:depression
schizophrenia
anxiety disorders
suicide risk
|
|
gptkbp:structure
|
7 transmembrane domains
|
|
gptkbp:type
|
inhibits adenylate cyclase
activates potassium channels
inhibits calcium channels
|
|
gptkbp:UniProtID
|
gptkb:P08908
|
|
gptkbp:bfsParent
|
gptkb:HT1
|
|
gptkbp:bfsLayer
|
7
|