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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Heat_shock_cognate_71_kDa_protein
gptkb:HSPA8
|
|
gptkbp:encodedBy
|
gptkb:HSPA8_gene
|
|
gptkbp:Entrez_Gene_ID
|
3312
|
|
gptkbp:expressedIn
|
all human tissues
|
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gptkbp:expressionLevel
|
constitutively expressed
|
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gptkbp:family
|
gptkb:HSP70_family
|
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gptkbp:function
|
protein folding
protein transport
molecular chaperone
prevention of protein aggregation
|
|
gptkbp:GO_term
|
gptkb:GO:0006457_(protein_folding)
GO:0005524 (ATP binding)
GO:0005737 (cytoplasm)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSC70
|
|
gptkbp:interactsWith
|
gptkb:CHIP
gptkb:BAG1
gptkb:BAG3
gptkb:HSP90
gptkb:HSP40
DNAJ proteins
|
|
gptkbp:involvedIn
|
autophagy
stress response
antigen processing
clathrin-mediated endocytosis
|
|
gptkbp:locatedOnChromosome
|
chromosome 6q23.3
|
|
gptkbp:location
|
gptkb:lysosome
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
71 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:3ATX
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
upregulated by stress
regulated by heat shock factor 1
|
|
gptkbp:requires
|
cell survival
protein homeostasis
|
|
gptkbp:significance
|
implicated in cancer
implicated in neurodegenerative diseases
implicated in infectious diseases
|
|
gptkbp:structure
|
ATPase domain
substrate-binding domain
|
|
gptkbp:UniProtID
|
P11142
|
|
gptkbp:bfsParent
|
gptkb:HSPA8
gptkb:P34972
|
|
gptkbp:bfsLayer
|
8
|