|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:HSC70
HSP73
HSC71
HSP70-8
HSP70.1
HSP70.2
HSP70c
|
|
gptkbp:alternativeName
|
gptkb:HSC70
gptkb:HSPA8
HSP73
|
|
gptkbp:associatedWith
|
cellular stress response
|
|
gptkbp:encodes
|
gptkb:Heat_shock_cognate_71_kDa_protein
|
|
gptkbp:Entrez_Gene_ID
|
3312
ENSG00000109971
|
|
gptkbp:expressedIn
|
gptkb:endoplasmic_reticulum
gptkb:nucleus
gptkb:cytoplasm
mitochondria
ubiquitous tissue expression
|
|
gptkbp:function
|
protein folding
protein transport
prevention of protein aggregation
chaperone activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSPA8 gene
|
|
gptkbp:involvedIn
|
apoptosis
cell cycle regulation
protein degradation
autophagy
antigen processing
protein refolding
|
|
gptkbp:length
|
646 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
|
|
gptkbp:memberOf
|
gptkb:heat_shock_protein_70_family
|
|
gptkbp:molecularWeight
|
71 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:OMIM
|
600816
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Hspa8
|
|
gptkbp:proteinFamily
|
C-terminal domain
ATPase domain
substrate-binding domain
|
|
gptkbp:regulates
|
transcription factors
heat shock
cellular stress
|
|
gptkbp:UniProtID
|
P11142
|
|
gptkbp:bfsParent
|
gptkb:HSPA8
|
|
gptkbp:bfsLayer
|
8
|