|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:familial_hypercholesterolemia
|
|
gptkbp:encodes
|
gptkb:HMG-CoA_reductase
|
|
gptkbp:Entrez_Gene_ID
|
3156
|
|
gptkbp:enzymeCommissionNumber
|
EC 1.1.1.34
|
|
gptkbp:fullName
|
gptkb:3-hydroxy-3-methylglutaryl-CoA_reductase
|
|
gptkbp:function
|
catalyzes conversion of HMG-CoA to mevalonate
|
|
gptkbp:GO_term
|
GO:0004420
|
|
gptkbp:HGNC_ID
|
5006
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hmgcr
|
|
gptkbp:inhibitedBy
|
gptkb:mevalonate
statins
|
|
gptkbp:length
|
888 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
|
|
gptkbp:location
|
5q13.3-q14
|
|
gptkbp:molecularWeight
|
97 kDa
|
|
gptkbp:mutationAssociatedWith
|
statin intolerance
mevalonic aciduria
|
|
gptkbp:OMIM
|
142910
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
cholesterol biosynthesis
|
|
gptkbp:regulates
|
gptkb:glucagon
gptkb:insulin
gptkb:AMPK
SREBP
|
|
gptkbp:subcellularLocation
|
endoplasmic reticulum membrane
|
|
gptkbp:target
|
statins
|
|
gptkbp:UniProtID
|
P04035
|
|
gptkbp:bfsParent
|
gptkb:HMGCR
|
|
gptkbp:bfsLayer
|
7
|