3-hydroxy-3-methylglutaryl-CoA reductase
GPTKB entity
Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:HMG-CoA_reductase
gptkb:HMGCR |
| gptkbp:biologicalProcess |
oxidoreductase activity
|
| gptkbp:catalyzes |
conversion of HMG-CoA to mevalonate
|
| gptkbp:cofactor |
NADPH
|
| gptkbp:EC_number |
1.1.1.34
|
| gptkbp:foundIn |
animals
humans plants |
| gptkbp:gene |
gptkb:HMGCR
|
| https://www.w3.org/2000/01/rdf-schema#label |
3-hydroxy-3-methylglutaryl-CoA reductase
|
| gptkbp:inhibitedBy |
statins
|
| gptkbp:involvedIn |
gptkb:mevalonate_pathway
cholesterol biosynthesis |
| gptkbp:location |
endoplasmic reticulum membrane
|
| gptkbp:regulates |
regulated by phosphorylation
feedback inhibition by cholesterol regulated by SREBP |
| gptkbp:significance |
target of cholesterol-lowering drugs
|
| gptkbp:UniProtID |
P04035
|
| gptkbp:bfsParent |
gptkb:HMG-CoA_reductase
gptkb:HMGCR |
| gptkbp:bfsLayer |
7
|