Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:HMG-CoA_reductase
|
| gptkbp:associatedWith |
gptkb:familial_hypercholesterolemia
|
| gptkbp:biologicalProcess |
lipid metabolism
oxidoreductase activity |
| gptkbp:cellularComponent |
endoplasmic reticulum membrane
|
| gptkbp:encodes |
gptkb:3-hydroxy-3-methylglutaryl-CoA_reductase
|
| gptkbp:Entrez_Gene_ID |
3156
|
| gptkbp:enzymeCommissionNumber |
EC 1.1.1.34
|
| gptkbp:function |
catalyzes conversion of HMG-CoA to mevalonate
|
| gptkbp:hasTranscriptVariant |
multiple splice variants
|
| https://www.w3.org/2000/01/rdf-schema#label |
HMGCR1
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_5
|
| gptkbp:location |
5q13.3-q14
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
gptkb:Hmgcr
|
| gptkbp:pathway |
cholesterol biosynthesis
|
| gptkbp:regulates |
feedback inhibited by cholesterol
|
| gptkbp:target |
statins
|
| gptkbp:UniProtID |
P04035
|
| gptkbp:bfsParent |
gptkb:HMGCR
|
| gptkbp:bfsLayer |
7
|