|
gptkbp:instanceOf
|
Ensembl gene ID
|
|
gptkbp:alias
|
gptkb:BZS
gptkb:MHAM
gptkb:MMAC1
gptkb:PTEN1
gptkb:TEP1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Bannayan-Riley-Ruvalcaba_syndrome
gptkb:Cowden_syndrome
gptkb:Lhermitte-Duclos_disease
gptkb:endometrial_cancer
prostate cancer
|
|
gptkbp:biologicalProcess
|
apoptosis
cell proliferation
cell cycle regulation
cell migration
protein tyrosine phosphatase activity
|
|
gptkbp:discoveredBy
|
Li J et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171862
5728
|
|
gptkbp:essentialGene
|
true
|
|
gptkbp:fullName
|
gptkb:phosphatase_and_tensin_homolog
|
|
gptkbp:function
|
tumor suppressor
phosphatase activity
|
|
gptkbp:gene
|
gptkb:PTEN
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPseudogene
|
gptkb:PTENP1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:9342
|
|
gptkbp:isProteinCoding
|
true
|
|
gptkbp:isTumorSuppressor
|
true
|
|
gptkbp:length
|
403 amino acids
|
|
gptkbp:locatedOnChromosome
|
10
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locusType
|
gptkb:10q23.31
|
|
gptkbp:mutationAssociatedWith
|
germline
somatic
|
|
gptkbp:omimID
|
601728
|
|
gptkbp:orthologInMouse
|
Pten
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:proteinFamily
|
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:refersTo
|
gptkb:PTEN
|
|
gptkbp:RefSeq
|
gptkb:NM_000314
|
|
gptkbp:regulates
|
gptkb:PI3K_pathway
Akt signaling
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:P60484
|
|
gptkbp:bfsParent
|
gptkb:PRPE2
|
|
gptkbp:bfsLayer
|
7
|