|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NEU
gptkb:CD340
HER2
MLN 19
|
|
gptkbp:alternativeName
|
gptkb:HER2/neu
gptkb:CD340
MLN 19
p185HER2
|
|
gptkbp:approvedBy
|
erb-b2 receptor tyrosine kinase 2
|
|
gptkbp:approvedSymbol
|
gptkb:ERBB2
|
|
gptkbp:associatedWith
|
gptkb:cancer
gastric cancer
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:Entrez_Gene_ID
|
2064
ENSG00000141736
|
|
gptkbp:expressedIn
|
epithelial cells
|
|
gptkbp:function
|
receptor tyrosine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
3775
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:3775
|
|
gptkbp:length
|
1255 amino acids
|
|
gptkbp:locatedOnChromosome
|
17
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:locusType
|
gptkb:17q12
|
|
gptkbp:molecularWeight
|
~137 kDa
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
drug resistance
|
|
gptkbp:OMIM
|
164870
|
|
gptkbp:orthologInMouse
|
Erbb2
|
|
gptkbp:overexpressedIn
|
breast cancer cells
gastric cancer cells
ovarian cancer cells
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:ErbB_signaling_pathway
|
|
gptkbp:previousSymbols
|
gptkb:NEU
gptkb:CD340
HER2
|
|
gptkbp:product
|
Receptor tyrosine-protein kinase erbB-2
|
|
gptkbp:proteinFamily
|
protein tyrosine kinase
EGF receptor family
|
|
gptkbp:RefSeq
|
NM_004448
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:symbol_status
|
approved
|
|
gptkbp:targetOfDrug
|
gptkb:pertuzumab
gptkb:trastuzumab
gptkb:tucatinib
gptkb:lapatinib
gptkb:neratinib
|
|
gptkbp:UniProtID
|
gptkb:P04626
|
|
gptkbp:bfsParent
|
gptkb:FMR1
|
|
gptkbp:bfsLayer
|
7
|