|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BZS
gptkb:MGC11227
gptkb:MHAM
gptkb:MMAC1
gptkb:PTEN1
gptkb:TEP1
|
|
gptkbp:approvalYear
|
1997
|
|
gptkbp:approvedBy
|
gptkb:phosphatase_and_tensin_homolog
|
|
gptkbp:approvedSymbol
|
gptkb:PTEN
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Bannayan-Riley-Ruvalcaba_syndrome
gptkb:Cowden_syndrome
gptkb:Lhermitte-Duclos_disease
gptkb:endometrial_cancer
gptkb:glioblastoma
gptkb:macrocephaly-autism_syndrome
melanoma
prostate cancer
|
|
gptkbp:component
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171862
5728
|
|
gptkbp:enzyme
|
true
|
|
gptkbp:essentialGene
|
yes
|
|
gptkbp:function
|
tumor suppressor
phosphatase activity
protein tyrosine phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
negative regulation of cell proliferation
negative regulation of PI3K signaling
|
|
gptkbp:hasPseudogene
|
yes
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:10874
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:10874
|
|
gptkbp:isImprinted
|
no
|
|
gptkbp:isTumorSuppressor
|
true
|
|
gptkbp:length
|
403 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q23.31
10
|
|
gptkbp:location
|
gptkb:10q23.31
|
|
gptkbp:locusType
|
gene with protein product
|
|
gptkbp:OMIM
|
601728
|
|
gptkbp:orthologIn
|
PTEN (mouse)
Pten (rat)
|
|
gptkbp:previousName
|
gptkb:mutated_in_multiple_advanced_cancers_1
TGF-beta-regulated and epithelial cell-enriched phosphatase
|
|
gptkbp:previousSymbols
|
gptkb:MMAC1
gptkb:TEP1
|
|
gptkbp:proteinFamily
|
gptkb:protein_tyrosine_phosphatases
tumor suppressors
|
|
gptkbp:RefSeq
|
gptkb:NM_000314
|
|
gptkbp:strand
|
minus
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:symbol
|
approved
|
|
gptkbp:UniProtID
|
gptkb:P60484
|
|
gptkbp:bfsParent
|
gptkb:Siglec-8
gptkb:CD329
|
|
gptkbp:bfsLayer
|
8
|