|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:RPD3
gptkb:HD2
gptkb:YAF1
KIAA0600
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
chromatin modification
histone deacetylase activity
transcriptional repression
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
HDAC2 protein
|
|
gptkbp:Entrez_Gene_ID
|
3066
ENSG00000196591
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_2
|
|
gptkbp:function
|
regulation of gene expression
histone deacetylation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
4853
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC2 gene
|
|
gptkbp:inhibitedBy
|
gptkb:valproic_acid
gptkb:trichostatin_A
gptkb:vorinostat
|
|
gptkbp:interactsWith
|
gptkb:NuRD_complex
CoREST complex
HDAC1 protein
Sin3A complex
|
|
gptkbp:length
|
approximately 24 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
gptkb:6q21
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
altered gene expression
|
|
gptkbp:numberOfExons
|
15
|
|
gptkbp:OMIM
|
605164
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Hdac2
|
|
gptkbp:pathway
|
DNA repair
cell cycle regulation
epigenetic regulation
|
|
gptkbp:proteinFamily
|
gptkb:enzyme
histone deacetylase family
|
|
gptkbp:referenceGenome
|
NM_001527
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:target
|
HDAC inhibitors
|
|
gptkbp:UniProtID
|
Q92769
|
|
gptkbp:bfsParent
|
gptkb:HDAC2
|
|
gptkbp:bfsLayer
|
7
|