|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:GAD
gptkb:GAD65
gptkb:GAD67
|
|
gptkbp:associatedWith
|
gptkb:autism_spectrum_disorder
epilepsy
schizophrenia
stiff-person syndrome
type 1 diabetes (autoantigen)
|
|
gptkbp:biologicalProcess
|
gptkb:GABA_biosynthetic_process
glutamate decarboxylase activity
|
|
gptkbp:catalyzes
|
decarboxylation of glutamate to GABA
|
|
gptkbp:chromosome_location_(GAD1)
|
gptkb:chromosome_2q31
|
|
gptkbp:chromosome_location_(GAD2)
|
gptkb:chromosome_10p11.23
|
|
gptkbp:cofactor
|
gptkb:pyridoxal_phosphate
|
|
gptkbp:EC_number
|
4.1.1.15
|
|
gptkbp:Enzyme_Commission_class
|
gptkb:Lyase
|
|
gptkbp:Enzyme_Commission_subclass
|
Carboxy-lyases
|
|
gptkbp:expressedIn
|
gptkb:pancreatic_islets
central nervous system
|
|
gptkbp:family
|
pyridoxal-dependent decarboxylase family
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
plants
|
|
gptkbp:gene
|
gptkb:GAD1
gptkb:GAD2
|
|
gptkbp:GO_term
|
gptkb:GO:0004351
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Glutamate Decarboxylase
|
|
gptkbp:inhibitedBy
|
gptkb:vigabatrin
gptkb:aminooxyacetic_acid
|
|
gptkbp:locale
|
gptkb:cytoplasm
synaptic vesicles
|
|
gptkbp:molecular_weight_(GAD65)
|
65 kDa
|
|
gptkbp:molecular_weight_(GAD67)
|
67 kDa
|
|
gptkbp:OMIM_ID_(GAD1)
|
605363
|
|
gptkbp:OMIM_ID_(GAD2)
|
138275
|
|
gptkbp:orthologInMouse
|
gptkb:Gad1
gptkb:Gad2
|
|
gptkbp:PDB_ID_(structure)
|
1PMM
2OKK
|
|
gptkbp:product
|
gptkb:gamma-aminobutyric_acid
|
|
gptkbp:role
|
GABAergic neurotransmission
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:L-glutamate
|
|
gptkbp:UniProt_ID_(GAD1)
|
gptkb:Q99259
|
|
gptkbp:UniProt_ID_(GAD2)
|
gptkb:Q9NZ42
|
|
gptkbp:bfsParent
|
gptkb:GAD
|
|
gptkbp:bfsLayer
|
7
|