Glucose-6-phosphate dehydrogenase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:alternativeName	gptkb:G6PD gptkb:G6PDH glucose-6-phosphate:NADP+ oxidoreductase
gptkbp:catalyzes	oxidation of glucose-6-phosphate to 6-phosphoglucono-δ-lactone
gptkbp:cofactor	NADP+
gptkbp:deficiencyCauses	gptkb:anemia
gptkbp:discoveredBy	gptkb:Ernest_Beutler
gptkbp:EC_number	1.1.1.49
gptkbp:foundIn	gptkb:cytoplasm
gptkbp:gene	gptkb:G6PD
gptkbp:highest_activity_in	liver red blood cells adrenal cortex
https://www.w3.org/2000/01/rdf-schema#label	Glucose-6-phosphate dehydrogenase
gptkbp:mutationAssociatedWith	gptkb:G6PD_deficiency
gptkbp:OMIM	305900
gptkbp:pathway	gptkb:pentose_phosphate_pathway
gptkbp:PDB	2BH9
gptkbp:presentIn	all cells
gptkbp:product	gptkb:6-phosphoglucono-δ-lactone NADPH
gptkbp:regulates	activated by NADP+ inhibited by NADPH
gptkbp:requires	protection against oxidative stress
gptkbp:structure	homodimer
gptkbp:substrate	gptkb:glucose-6-phosphate
gptkbp:UniProtID	P11413
gptkbp:bfsParent	gptkb:P37023 gptkb:P45381 gptkb:G6PD_protein gptkb:human_G6PD_protein
gptkbp:bfsLayer	7