|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:G6PDH
gptkb:G6P_dehydrogenase
|
|
gptkbp:associatedWith
|
gptkb:G6PD_deficiency
gptkb:anemia
|
|
gptkbp:biologicalProcess
|
gptkb:pentose_phosphate_pathway
oxidative stress response
NADPH production
|
|
gptkbp:cofactor
|
NADP+
|
|
gptkbp:EC_number
|
1.1.1.49
|
|
gptkbp:encodedBy
|
gptkb:G6PD_gene
|
|
gptkbp:Entrez_Gene_ID
|
2539
|
|
gptkbp:enzyme
|
true
|
|
gptkbp:fullName
|
gptkb:Glucose-6-phosphate_dehydrogenase
|
|
gptkbp:function
|
catalyzes the first step in the pentose phosphate pathway
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
G6PD protein
|
|
gptkbp:isAllosteric
|
false
|
|
gptkbp:locatedOnChromosome
|
gptkb:Xq28
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
59 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause G6PD deficiency
|
|
gptkbp:OMIM
|
305900
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:2BHL
2BH9
|
|
gptkbp:product
|
gptkb:6-phosphoglucono-δ-lactone
NADPH
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:significance
|
gptkb:neonatal_jaundice
gptkb:favism
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:glucose-6-phosphate
|
|
gptkbp:targetOfDrug
|
true
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
P11413
|
|
gptkbp:bfsParent
|
gptkb:NP_000445.1
|
|
gptkbp:bfsLayer
|
6
|