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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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PEBP1
phosphatidylethanolamine-binding protein 1
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gptkbp:discoveredBy
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1999
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gptkbp:encodedBy
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PEBP1 gene
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gptkbp:fullName
|
Raf kinase inhibitor protein
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gptkbp:function
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regulates MAPK signaling pathway
inhibits NF-κB signaling pathway
inhibits Raf-1 kinase
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gptkbp:gene
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PEBP1
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https://www.w3.org/2000/01/rdf-schema#label
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RKIP
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gptkbp:interactsWith
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gptkb:MEK
gptkb:GRK2
Raf-1
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gptkbp:locatedOnChromosome
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chromosome 12q12-q13
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gptkbp:location
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:molecularWeight
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21 kDa
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:PDB
|
1BEH
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gptkbp:phosphorylates
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Ser153
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gptkbp:regulates
|
expression downregulated in some cancers
phosphorylation by PKC
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gptkbp:role
|
tumor suppressor
implicated in cancer progression
metastasis suppressor
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gptkbp:speciesHomologs
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gptkb:mouse
gptkb:zebrafish
right
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gptkbp:structure
|
contains PEBP domain
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gptkbp:UniProtID
|
P30086
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gptkbp:bfsParent
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gptkb:Negative_regulation_of_MAPK_pathway
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gptkbp:bfsLayer
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7
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