|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:G_proteins
|
|
gptkbp:associatedWith
|
gptkb:cancer
cardiovascular diseases
neurological disorders
metabolic disorders
|
|
gptkbp:binds
|
ligands
|
|
gptkbp:database
|
gptkb:GPCRdb
gptkb:IUPHAR/BPS_Guide_to_Pharmacology
|
|
gptkbp:discoveredBy
|
gptkb:Martin_Rodbell
gptkb:Alfred_G._Gilman
|
|
gptkbp:encodedBy
|
GPCR genes
|
|
gptkbp:example
|
gptkb:receptor_tyrosine_kinase
gptkb:beta-adrenergic_receptor
gptkb:muscarinic_acetylcholine_receptor
gptkb:olfactory_receptor
gptkb:rhodopsin
dopamine receptor
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
signal transduction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GPCR
|
|
gptkbp:importantFor
|
pharmaceutical research
|
|
gptkbp:involvedIn
|
sensory perception
immune response
neurotransmission
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:modulatedBy
|
antagonists
allosteric modulators
agonists
inverse agonists
|
|
gptkbp:NobelPrizeYear
|
Nobel Prize in Chemistry 2012
|
|
gptkbp:numberOfGenes
|
over 800
|
|
gptkbp:orthologIn
|
animals
fungi
plants
|
|
gptkbp:regulates
|
phosphorylation
desensitization
internalization
arrestins
|
|
gptkbp:signalVia
|
gptkb:IP3
gptkb:cAMP
gptkb:DAG
second messengers
calcium ions
|
|
gptkbp:standsFor
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:subclassOf
|
gptkb:Class_A_(Rhodopsin-like)
gptkb:Class_B_(Secretin_receptor_family)
gptkb:Class_C_(Metabotropic_glutamate/pheromone)
gptkb:Class_F_(Frizzled/Smoothened)
|
|
gptkbp:target
|
many drugs
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:bfsLayer
|
5
|