GLP-1 (Glucagon-like peptide-1)

URI: https://gptkb.org/entity/GLP-1_(Glucagon-like_peptide-1)
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf peptide
gptkbp:actsOn brain
heart
central nervous system
liver
pancreas
stomach
gptkbp:affects pancreatic beta cells
pancreatic alpha cells
gptkbp:agonistDrugs gptkb:albiglutide
gptkb:exenatide
gptkb:liraglutide
gptkb:lixisenatide
gptkb:semaglutide
gptkb:dulaglutide
gptkbp:category gut hormone
incretin hormone
gptkbp:decreasedIn beta cell apoptosis
gptkbp:degradedBy gptkb:DPP-4_enzyme
gptkbp:discoveredIn 1980s
gptkbp:encodedBy gptkb:GCG_gene
gptkbp:halfLife 1-2 minutes
https://www.w3.org/2000/01/rdf-schema#label GLP-1 (Glucagon-like peptide-1)
gptkbp:improves neuroprotection
beta cell proliferation
cardioprotection
glucose-dependent insulin secretion
insulin biosynthesis
satiety
gptkbp:inhibitedBy glucagon secretion
gptkbp:producedBy gptkb:intestinal_L-cells
gptkb:nucleus_of_the_solitary_tract
gptkbp:promotion gptkb:protein
glucose
fat
insulin secretion
nutrient ingestion
gptkbp:recipient gptkb:GLP-1_receptor
gptkbp:reduces appetite
body weight
food intake
gptkbp:sequence 7-36 amide
7-37
gptkbp:slows gastric emptying
gptkbp:usedIn obesity treatment
type 2 diabetes treatment
gptkbp:bfsParent gptkb:GLP
gptkbp:bfsLayer 6