G-protein-coupled receptors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:GPCRs
gptkbp:activatedBy	gptkb:G_proteins
gptkbp:alternativeName	seven-transmembrane receptors heptahelical receptors serpentine receptors
gptkbp:binds	ligands
gptkbp:database	gptkb:GPCRdb gptkb:UniProt gptkb:IUPHAR/BPS_Guide_to_Pharmacology
gptkbp:discoveredBy	gptkb:Robert_J._Lefkowitz gptkb:Brian_Kobilka
gptkbp:encodedBy	GPCR genes
gptkbp:example	gptkb:receptor_tyrosine_kinase gptkb:beta-adrenergic_receptor gptkb:muscarinic_acetylcholine_receptor gptkb:olfactory_receptor gptkb:rhodopsin dopamine receptor
gptkbp:foundIn	eukaryotes
gptkbp:function	signal transduction
https://www.w3.org/2000/01/rdf-schema#label	G-protein-coupled receptors
gptkbp:involvedIn	gptkb:DVD immune response taste smell neurotransmission hormone response
gptkbp:location	gptkb:cell_membrane
gptkbp:mechanismOfAction	conformational change upon ligand binding
gptkbp:NobelPrizeYear	2012 Chemistry
gptkbp:pathway	second messenger systems
gptkbp:percentageOfDrugsTargeting	~34%
gptkbp:proteinFamily	large
gptkbp:regulates	phosphorylation arrestin binding desensitization
gptkbp:relatedTo	gptkb:cancer gptkb:disease cardiovascular diseases neurological disorders metabolic disorders
gptkbp:structure	seven transmembrane alpha helices
gptkbp:subspecies	gptkb:secretin-like_receptors metabotropic glutamate receptors rhodopsin-like receptors
gptkbp:superfamily	membrane proteins
gptkbp:target	pharmaceutical drugs
gptkbp:transmembraneDomains	7
gptkbp:bfsParent	gptkb:G-proteins
gptkbp:bfsLayer	8