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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:FZD_receptors
gptkb:Frizzled_family_receptors
|
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gptkbp:associatedWith
|
gptkb:cancer
developmental disorders
|
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gptkbp:discoveredBy
|
gptkb:Harold_Varmus
|
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gptkbp:firstDescribed
|
1990s
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gptkbp:foundIn
|
animals
|
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gptkbp:function
|
Wnt signaling pathway receptor
|
|
gptkbp:GO_term
|
GO:0016021 (integral component of membrane)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Frizzled proteins
|
|
gptkbp:interactsWith
|
gptkb:Dishevelled_proteins
gptkb:LRP5/6
|
|
gptkbp:ligand
|
gptkb:Wnt_proteins
|
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gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:member
|
gptkb:FZD1
gptkb:FZD10
gptkb:FZD2
gptkb:FZD3
gptkb:FZD4
gptkb:FZD5
gptkb:FZD6
gptkb:FZD7
gptkb:FZD8
gptkb:FZD9
|
|
gptkbp:numberOfMembers
|
10 in humans
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:proteinFamily
|
gptkb:FZD_genes
PF01534 (Frizzled domain)
|
|
gptkbp:role
|
embryonic development
cell fate determination
stem cell maintenance
cell polarity
|
|
gptkbp:signalingType
|
non-canonical Wnt signaling
canonical Wnt signaling
|
|
gptkbp:structure
|
7 transmembrane domains
|
|
gptkbp:UniProtID
|
PTHR11361
|
|
gptkbp:bfsParent
|
gptkb:Frizzled_receptors
|
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gptkbp:bfsLayer
|
7
|