|
gptkbp:instanceOf
|
immune response
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:elevatedIn
|
gptkb:Mikulicz's_disease
retroperitoneal fibrosis
IgG4-related disease
autoimmune pancreatitis
|
|
gptkbp:encodedBy
|
IGHG4 gene
|
|
gptkbp:features
|
Fab-arm exchange
|
|
gptkbp:foundIn
|
human serum
|
|
gptkbp:function
|
immune response
anti-inflammatory activity
allergy regulation
|
|
gptkbp:halfLife
|
21 days
|
|
gptkbp:hasAntigenBindingSites
|
2
|
|
gptkbp:hasHeavyChain
|
gamma-4 chain
|
|
gptkbp:hasLightChain
|
kappa chain
lambda chain
|
|
gptkbp:hasLowAbilityTo
|
activate complement
|
|
gptkbp:hasLowAffinityFor
|
gptkb:Fc_gamma_receptors
|
|
gptkbp:hasLowPrevalence
|
in serum compared to other IgG subclasses
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IgG4
|
|
gptkbp:isotypeOf
|
gptkb:monoclonal_antibody
|
|
gptkbp:molecularWeight
|
146 kDa
|
|
gptkbp:normalSerumConcentration
|
0.035–0.51 g/L
|
|
gptkbp:significance
|
marker for autoimmune diseases
biomarker for IgG4-related disease
marker for allergy
|
|
gptkbp:structure
|
Y-shaped
|
|
gptkbp:subclassOf
|
gptkb:IgG
|
|
gptkbp:bfsParent
|
gptkb:dupilumab
gptkb:Libtayo
gptkb:nivolumab
|
|
gptkbp:bfsLayer
|
7
|