Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
immunoglobulin G subclass
|
| gptkbp:abundance |
most abundant IgG subclass in human serum
|
| gptkbp:associatedWith |
allergic reactions (rarely)
|
| gptkbp:binds |
gptkb:Fc_gamma_receptors
neonatal Fc receptor (FcRn) |
| gptkbp:encodedBy |
IGHG1 gene
|
| gptkbp:foundIn |
human serum
|
| gptkbp:function |
antibody-dependent cellular cytotoxicity
opsonization complement activation neutralization of pathogens |
| gptkbp:halfLife |
about 21 days
|
| gptkbp:hasHeavyChain |
gamma-1 chain
|
| https://www.w3.org/2000/01/rdf-schema#label |
IgG1
|
| gptkbp:isotypeOf |
gptkb:IgG
|
| gptkbp:medicalUse |
therapeutic monoclonal antibodies
|
| gptkbp:molecularWeight |
about 146 kDa
|
| gptkbp:presentIn |
extracellular fluids
|
| gptkbp:role |
secondary immune response
|
| gptkbp:structure |
monomer
|
| gptkbp:subclassOf |
gptkb:immunoglobulin_G
|
| gptkbp:bfsParent |
gptkb:ocrelizumab
gptkb:IgG1_kappa gptkb:UniProt:P01848 gptkb:trastuzumab gptkb:Praluent_(alirocumab) gptkb:REGEN-COV_(casirivimab_and_imdevimab) gptkb:3F2.1_(mouse) |
| gptkbp:bfsLayer |
7
|