|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:factor_VIIa-tissue_factor_complex
gptkb:factor_XIa
|
|
gptkbp:alternativeName
|
gptkb:Christmas_factor
plasma thromboplastin component
|
|
gptkbp:associatedWith
|
hemophilia B Leyden
|
|
gptkbp:cleavage
|
activated factor IX (factor IXa)
|
|
gptkbp:cofactor
|
gptkb:factor_VIIIa
phospholipids
calcium ions
|
|
gptkbp:deficiencyCauses
|
gptkb:hemophilia_B
|
|
gptkbp:discoveredBy
|
Rosalind Christmas
|
|
gptkbp:EC_number
|
3.4.21.22
|
|
gptkbp:encodedBy
|
gptkb:F9_gene
|
|
gptkbp:Entrez_Gene_ID
|
2158
|
|
gptkbp:expressedIn
|
gptkb:plasma
gptkb:hepatocytes
|
|
gptkbp:function
|
blood coagulation
activation of factor X
|
|
gptkbp:gene
|
gptkb:F9
|
|
gptkbp:HGNC_ID
|
HGNC:3551
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Factor IX (F9)
|
|
gptkbp:inhibitedBy
|
gptkb:antithrombin
gptkb:tissue_factor_pathway_inhibitor
gptkb:protein_Z-dependent_protease_inhibitor
|
|
gptkbp:length
|
34 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:X_chromosome
Xq27.1-q27.2
|
|
gptkbp:medicalUse
|
recombinant factor IX for hemophilia B treatment
|
|
gptkbp:molecularWeight
|
~55 kDa
|
|
gptkbp:mutationAssociatedWith
|
nonsense
deletion
insertion
missense
splice site
|
|
gptkbp:numberOfExons
|
8
|
|
gptkbp:OMIM
|
300746
|
|
gptkbp:orthologInDog
|
gptkb:F9
|
|
gptkbp:orthologInMouse
|
gptkb:F9
|
|
gptkbp:PDB
|
1RFN
|
|
gptkbp:postTranslationalModification
|
gamma-carboxylation
|
|
gptkbp:proteinFamily
|
gptkb:serine_protease
|
|
gptkbp:referenceGenome
|
NM_000133
|
|
gptkbp:referenceProteinSequence
|
NP_000124
|
|
gptkbp:synthesisType
|
liver
|
|
gptkbp:UniProtID
|
P00740
|
|
gptkbp:vitaminKDependent
|
true
|
|
gptkbp:bfsParent
|
gptkb:SPK-9001
|
|
gptkbp:bfsLayer
|
8
|