Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:anemia ovarian cancer solid tumors |
| gptkbp:function |
DNA repair
|
| gptkbp:genetic_studies |
causes Fanconi anemia type D3
|
| https://www.w3.org/2000/01/rdf-schema#label |
FANCD3
|
| gptkbp:interacts_with |
gptkb:BRCA2
gptkb:BRCA1 gptkb:FANCA gptkb:FANCB gptkb:FANCC gptkb:PALB2 gptkb:RAD51 |
| gptkbp:involved_in |
DNA replication
DNA damage response apoptosis cell cycle regulation cellular homeostasis cellular metabolism cellular stress response chromatin remodeling immune response signal transduction homologous recombination cellular proliferation cellular senescence genome stability cellular aging cellular differentiation protein degradation DNA methylation protein folding RNA processing cellular signaling pathways cellular adhesion cellular communication nuclear transport protein-protein interactions telomere maintenance cellular differentiation processes cellular migration cellular invasion cellular transport processes repair of double-strand breaks repair of single-strand breaks cell cycle checkpoint regulation cellular response to DNA damage stimulus interstrand cross-link repair repair of damaged DNA |
| gptkbp:is_expressed_in |
regulated by transcription factors
upregulated in response to DNA damage detected in various tissues increased in cancerous tissues |
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:orthologs |
FANCD3 in humans
FANCD3 in mice |
| gptkbp:pathway |
Fanconi anemia pathway
|
| gptkbp:promoter |
FANCD3 gene
|
| gptkbp:role |
monoubiquitination
|
| gptkbp:bfsParent |
gptkb:anemia
|
| gptkbp:bfsLayer |
5
|