Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:anatomy |
bone marrow
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:anemia ovarian cancer increased sensitivity to ionizing radiation potential therapeutic target chromosomal instability gene therapy research genetic predisposition to cancer clinical trials for targeted therapies increased risk of secondary cancers hypersensitivity to cisplatin CRISPR gene editing studies biomarker for cancer risk assessment cell cycle checkpoint defects defective DNA repair mechanisms genetic counseling for affected families hypersensitivity to chlorambucil hypersensitivity to cyclophosphamide hypersensitivity to mitomycin C increased apoptosis in response to DNA damage increased risk of hematological malignancies increased risk of solid tumors increased sensitivity to UV radiation increased sensitivity to alkylating agents increased sensitivity to oxidative stress reduced cell survival after DNA damage sensitivity to DNA cross-linking agents |
| gptkbp:breeding_range |
9q22.3
|
| gptkbp:clinical_trial |
important for hematopoiesis
|
| gptkbp:code |
FANCB protein
|
| gptkbp:discovery_year |
gptkb:1996
|
| gptkbp:diseases |
gptkb:Fanconi_anemia_type_A
|
| gptkbp:function |
DNA repair
|
| gptkbp:genetic_studies |
increased cancer risk
deletions insertions missense mutations nonsense mutations |
| https://www.w3.org/2000/01/rdf-schema#label |
FANCB
|
| gptkbp:interacts_with |
gptkb:FANCA
|
| gptkbp:is_expressed_in |
high in fetal tissues
low in adult tissues |
| gptkbp:is_tested_for |
genetic testing for Fanconi anemia
|
| gptkbp:located_in |
human chromosome 9
|
| gptkbp:nutritional_value |
contains a RING finger domain
contains a coiled-coil domain interacts with other Fanconi proteins contains a BRCA1 C-terminal domain |
| gptkbp:orthologs |
gptkb:mouse
rat |
| gptkbp:pathway |
DNA cross-link repair
|
| gptkbp:promoter |
gptkb:FANCB
Fanconi anemia genes |
| gptkbp:ref_seq |
NM_001456
|
| gptkbp:related_to |
gptkb:FANCC
gptkb:FANCM |
| gptkbp:research |
gene sequencing
|
| gptkbp:research_focus |
genetic disorders
|
| gptkbp:seed_dispersal |
protein-coding
|
| gptkbp:bfsParent |
gptkb:anemia
|
| gptkbp:bfsLayer |
5
|