Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
3
|
| gptkbp:bfsParent |
gptkb:fandom
|
| gptkbp:associated_with |
gptkb:fandom
increased cancer risk developmental delays solid tumors short stature increased risk of leukemia skin pigmentation changes |
| gptkbp:clinical_trial |
ongoing clinical trials
important for genetic testing |
| gptkbp:function |
DNA repair
|
| gptkbp:genetic_diversity |
available for families
deletions insertions missense mutations nonsense mutations bone marrow failure congenital abnormalities hypersensitivity to DNA cross-linking agents 16q24.3 causes Fanconi anemia multiple known alleles |
| https://www.w3.org/2000/01/rdf-schema#label |
FANCA
|
| gptkbp:intelligence |
FANCA in other species
|
| gptkbp:interacts_with |
other Fanconi anemia genes
with BRC A1 with FANC D2 with RA D51 with other FA proteins |
| gptkbp:is_a_route_for |
DNA cross-link repair
|
| gptkbp:is_represented_in |
high in bone marrow
in hematopoietic cells low in other tissues |
| gptkbp:located_in |
chromosome 16
|
| gptkbp:nutritional_value |
FANCA protein
involved in DNA repair complex |
| gptkbp:promoter |
gptkb:FANCA
FANCA gene family |
| gptkbp:research |
target for gene therapy
|
| gptkbp:research_areas |
gptkb:Company
molecular biology hematology pediatric oncology translational research gene therapy research genomic medicine cancer genetics clinical genetics |
| gptkbp:research_focus |
gene therapy approaches
|
| gptkbp:social_responsibility |
gptkb:Fanconi_anemia_type_A
|
| gptkbp:type |
tumor suppressor gene
|
| gptkbp:year_created |
gptkb:1996
|