|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:PTK2B
Protein Tyrosine Kinase 2 Beta
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
|
|
gptkbp:domain
|
gptkb:FAT_domain
kinase domain
FERM domain
|
|
gptkbp:encodedBy
|
PTK2B gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105221
2185
|
|
gptkbp:expressedIn
|
brain
immune cells
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:function
|
signal transduction
protein tyrosine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
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gptkbp:HGNC_ID
|
HGNC:9612
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FAK2
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:PTPN11
gptkb:SRC
gptkb:paxillin
gptkb:GRB2
|
|
gptkbp:involvedIn
|
cell migration
cell adhesion
regulation of cytoskeleton
|
|
gptkbp:locale
|
gptkb:cytoplasm
focal adhesions
|
|
gptkbp:locatedOnChromosome
|
chromosome 8p21.2
|
|
gptkbp:molecularWeight
|
116 kDa
|
|
gptkbp:OMIM
|
600758
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
Tyr402
Tyr579
Tyr580
Tyr881
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell survival
cell motility
|
|
gptkbp:relatedTo
|
focal adhesion kinase (FAK)
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:cytoplasm
focal adhesion
|
|
gptkbp:UniProtID
|
gptkb:Q14289
|
|
gptkbp:bfsParent
|
gptkb:PTK2B
|
|
gptkbp:bfsLayer
|
8
|