Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:affects |
stimulates angiogenesis
enhances cell migration increases mitosis |
| gptkbp:clinical_trial |
studied in Phase I trials
studied in Phase II trials studied in Phase III trials |
| gptkbp:clinical_use |
used in cancer treatment
used in skin care products |
| gptkbp:discovered_by |
gptkb:Stanley_Cohen
|
| gptkbp:discovery_year |
gptkb:1962
|
| gptkbp:diseases |
gptkb:diabetes
gptkb:ulcerative_colitis gptkb:Oncology psoriasis |
| gptkbp:ecological_role |
involved in embryogenesis
involved in organ development promotes epithelial cell proliferation |
| gptkbp:financial_stability |
sensitive to heat
stable at room temperature degraded by proteases |
| gptkbp:function |
involved in wound healing
promotes cell differentiation stimulates cell growth |
| https://www.w3.org/2000/01/rdf-schema#label |
Epidermal Growth Factor
|
| gptkbp:initiated_by |
monoclonal antibodies
EGFR inhibitors |
| gptkbp:interacts_with |
interacts with EGFR
interacts with heparin interacts with integrins |
| gptkbp:location |
found in human saliva
found in urine |
| gptkbp:pathway |
EGF signaling pathway
|
| gptkbp:promoter |
EGF gene
|
| gptkbp:regulatory_compliance |
regulated by cytokines
regulated by growth factors regulated by hormones |
| gptkbp:related_to |
EGFR (Epidermal Growth Factor Receptor)
|
| gptkbp:research_areas |
cancer research
used in regenerative medicine regenerative medicine research dermatological research used in oncology used in dermatology |
| gptkbp:role |
cell signaling
immune response tissue repair |
| gptkbp:shipping_options |
administered intravenously
administered subcutaneously administered topically |
| gptkbp:source |
produced by fibroblasts
produced by keratinocytes produced by macrophages |
| gptkbp:type |
gptkb:Cell
growth factor |
| gptkbp:weight |
6.045 k Da
|
| gptkbp:bfsParent |
gptkb:EGFR
|
| gptkbp:bfsLayer |
5
|