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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:EGF
|
|
gptkbp:binds
|
gptkb:Epidermal_Growth_Factor_Receptor
|
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gptkbp:category
|
growth factor
signaling molecule
mitogen
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_Cohen
|
|
gptkbp:Entrez_Gene_ID
|
1950 (NCBI)
ENSG00000138798
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|
gptkbp:firstIsolatedFrom
|
mouse submaxillary gland
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gptkbp:foundIn
|
humans
mice
other mammals
|
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gptkbp:function
|
stimulates cell growth
stimulates cell proliferation
stimulates cell differentiation
|
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gptkbp:gene
|
gptkb:EGF_gene
|
|
gptkbp:HGNC_ID
|
3229
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Epidermal Growth Factor
|
|
gptkbp:inhibitedBy
|
gastric acid secretion
|
|
gptkbp:involvedIn
|
embryonic development
angiogenesis
tissue regeneration
tumorigenesis
|
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gptkbp:locatedOnChromosome
|
chromosome 4q25-q27 (human)
|
|
gptkbp:medicalUse
|
wound healing
treatment of burns
treatment of ulcers
|
|
gptkbp:molecularWeight
|
~6 kDa (human)
|
|
gptkbp:NobelPrizeYear
|
Stanley Cohen (1986 Nobel Prize in Physiology or Medicine)
|
|
gptkbp:OMIM
|
131530
|
|
gptkbp:orthologIn
|
gptkb:amphiregulin
gptkb:betacellulin
gptkb:epiregulin
gptkb:transforming_growth_factor_alpha_(TGF-α)
gptkb:heparin-binding_EGF-like_growth_factor_(HB-EGF)
|
|
gptkbp:producedBy
|
various tissues
|
|
gptkbp:promotion
|
fibroblast proliferation
epithelial cell proliferation
|
|
gptkbp:recipient
|
gptkb:EGFR
|
|
gptkbp:relatedTo
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
cancer progression
cell signaling pathways
|
|
gptkbp:sequence
|
53 amino acids (human)
|
|
gptkbp:structure
|
contains three disulfide bonds
|
|
gptkbp:symbol
|
gptkb:EGF
|
|
gptkbp:UniProtID
|
P01133
|
|
gptkbp:bfsParent
|
gptkb:EGF
|
|
gptkbp:bfsLayer
|
7
|