|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:ESR1
ERα
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:bone
gptkb:endometrial_cancer
|
|
gptkbp:binds
|
estrogen
|
|
gptkbp:discoveredBy
|
gptkb:Elwood_V._Jensen
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:encodedBy
|
ESR1 gene
|
|
gptkbp:Entrez_Gene_ID
|
2099
|
|
gptkbp:expressedIn
|
gptkb:endometrium
gptkb:bone
gptkb:prostate
gptkb:testis
breast tissue
|
|
gptkbp:form
|
homodimer
heterodimer with estrogen receptor 2
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
3467
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
estrogen receptor 1
|
|
gptkbp:inhibitedBy
|
aromatase inhibitors
SERDs
SERMs
|
|
gptkbp:interactsWith
|
coactivators
corepressors
|
|
gptkbp:locatedIn
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
6q25.1
|
|
gptkbp:memberOf
|
gptkb:nuclear_hormone_receptor_family
|
|
gptkbp:molecularWeight
|
66 kDa
|
|
gptkbp:mutationAssociatedWith
|
hormone resistance
breast cancer progression
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
1A52
|
|
gptkbp:phosphorylates
|
gptkb:MAPK
gptkb:CDK2
|
|
gptkbp:RefSeq
|
gptkb:NM_000125
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
gene expression
|
|
gptkbp:structure
|
DNA-binding domain
ligand-binding domain
activation function domain
|
|
gptkbp:target
|
gptkb:fulvestrant
gptkb:tamoxifen
raloxifene
|
|
gptkbp:UniProtID
|
gptkb:P03372
|
|
gptkbp:bfsParent
|
gptkb:ESR1
|
|
gptkbp:bfsLayer
|
7
|