|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
SEK
EphA4
HEK8
|
|
gptkbp:associatedWith
|
amyotrophic lateral sclerosis
spinal muscular atrophy
|
|
gptkbp:biologicalProcess
|
cell migration
ATP binding
protein tyrosine kinase activity
axonogenesis
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:encodes
|
Ephrin type-A receptor 4 protein
|
|
gptkbp:Entrez_Gene_ID
|
2043
ENSG00000146904
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
various tissues
|
|
gptkbp:fullName
|
Ephrin type-A receptor 4
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
3227
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EPHA4
|
|
gptkbp:interactsWith
|
gptkb:PTPN13
gptkb:GRB2
gptkb:NCK1
FYN
EFNA1
EFNA3
EFNA5
VAV2
EFNA4
|
|
gptkbp:involves
|
cell signaling
nervous system development
axon guidance
|
|
gptkbp:length
|
986
|
|
gptkbp:locatedOnChromosome
|
2
|
|
gptkbp:location
|
2q36.1
|
|
gptkbp:molecularWeight
|
109 kDa
|
|
gptkbp:mutationAssociatedWith
|
impaired axon regeneration
motor neuron disease susceptibility
|
|
gptkbp:OMIM
|
179610
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Epha4
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
axon guidance pathway
Ephrin signaling pathway
|
|
gptkbp:PDB
|
2QBX
2Y6M
4M4P
|
|
gptkbp:phosphorylates
|
Y596
Y602
Y779
|
|
gptkbp:proteinFamily
|
gptkb:Eph_receptor_family
|
|
gptkbp:regulates
|
gptkb:synaptic_plasticity
autophosphorylation
ligand binding
dendritic spine morphology
|
|
gptkbp:UniProtID
|
P54764
|
|
gptkbp:bfsParent
|
gptkb:EPHA
|
|
gptkbp:bfsLayer
|
7
|