Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:ESA
gptkb:CD326 KS1/4 TACSTD1 GA733-2 |
| gptkbp:associatedWith |
gptkb:Lynch_syndrome
gptkb:congenital_tufting_enteropathy various carcinomas |
| gptkbp:clinicalTrialPhase |
immunohistochemistry
genetic testing for Lynch syndrome |
| gptkbp:discoveredBy |
L. Moldenhauer et al.
|
| gptkbp:encodes |
EPCAM protein
|
| gptkbp:Entrez_Gene_ID |
4072
ENSG00000119888 |
| gptkbp:expressedIn |
epithelial tissues
|
| gptkbp:firstDescribed |
1979
|
| gptkbp:fullName |
epithelial cell adhesion molecule
|
| gptkbp:function |
cell proliferation
differentiation cell signaling cell adhesion |
| gptkbp:HGNC_ID |
gptkb:EPCAM
|
| https://www.w3.org/2000/01/rdf-schema#label |
EPCAM gene
|
| gptkbp:interactsWith |
gptkb:CD44
gptkb:beta-catenin gptkb:E-cadherin claudins |
| gptkbp:length |
314 amino acids
|
| gptkbp:locatedOnChromosome |
2
2p21 |
| gptkbp:location |
gptkb:cell_membrane
basolateral membrane of epithelial cells |
| gptkbp:molecularWeight |
35-40 kDa
|
| gptkbp:mutationAssociatedWith |
loss of function causes congenital tufting enteropathy
deletion can cause Lynch syndrome |
| gptkbp:OMIM |
185535
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
mouse EpCAM
rat EpCAM zebrafish epcam |
| gptkbp:postTranslationalModification |
phosphorylation
glycosylation |
| gptkbp:product |
transmembrane glycoprotein
|
| gptkbp:proteinFamily |
TACSTD family
|
| gptkbp:regulates |
regulated by Wnt signaling
regulated by transcription factors |
| gptkbp:therapeuticAntibody |
catumaxomab
edrecolomab |
| gptkbp:UniProtID |
P16422
|
| gptkbp:usedAs |
therapeutic target
cancer stem cell marker diagnostic marker in carcinomas |
| gptkbp:bfsParent |
gptkb:CD326
|
| gptkbp:bfsLayer |
7
|