|
gptkbp:instanceOf
|
gptkb:hereditary_cancer_syndrome
|
|
gptkbp:abbreviation
|
gptkb:HNPCC
|
|
gptkbp:alsoKnownAs
|
gptkb:hereditary_nonpolyposis_colorectal_cancer
|
|
gptkbp:associatedWith
|
microsatellite instability
|
|
gptkbp:category
|
gptkb:syndrome
gptkb:genetic_disorder
gptkb:cancer_predisposition_syndrome
|
|
gptkbp:compatibleWith
|
gptkb:familial_adenomatous_polyposis
|
|
gptkbp:diagnosedBy
|
gptkb:Amsterdam_criteria
gptkb:Bethesda_guidelines
genetic testing
|
|
gptkbp:eponymOf
|
gptkb:Henry_T._Lynch
|
|
gptkbp:firstDescribed
|
gptkb:Henry_T._Lynch
|
|
gptkbp:hasGeneticCounseling
|
yes
|
|
gptkbp:hasNoPolyposis
|
yes
|
|
gptkbp:hasSurveillanceRecommendations
|
yes
|
|
gptkbp:hasVariableExpressivity
|
yes
|
|
gptkbp:hasVariablePenetrance
|
yes
|
|
gptkbp:ICD-10_code
|
Z15.0
|
|
gptkbp:inheritsFrom
|
autosomal dominant manner
|
|
gptkbp:MeSH_ID
|
D018223
|
|
gptkbp:mutationAssociatedWith
|
gptkb:MLH1
gptkb:MSH2
gptkb:MSH6
gptkb:PMS2
gptkb:EPCAM
|
|
gptkbp:namedAfter
|
gptkb:Henry_T._Lynch
|
|
gptkbp:OMIM
|
120435
|
|
gptkbp:parent
|
gptkb:hereditary_cancer_syndrome
|
|
gptkbp:prevalence
|
1 in 300 people
|
|
gptkbp:riskFactor
|
gptkb:cancer
gptkb:endometrial_cancer
gptkb:small_bowel_cancer
colorectal cancer
pancreatic cancer
stomach cancer
brain cancer
urinary tract cancer
|
|
gptkbp:symptom
|
gptkb:early_onset_colorectal_cancer
multiple primary cancers
|
|
gptkbp:treatment
|
chemoprevention
regular cancer screening
prophylactic surgery
|
|
gptkbp:bfsParent
|
gptkb:endometrial_cancer
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lynch syndrome
|