gptkbp:instanceOf
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gptkb:protein
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gptkbp:alias
|
EIF4EBP-1
eIF-4E-binding protein 1
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gptkbp:alternativeName
|
gptkb:4E-BP1
gptkb:PHAS-I
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gptkbp:associatedWith
|
gptkb:cancer
metabolic disorders
EIF4EBP2
EIF4EBP3
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000187840
1978
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gptkbp:expressedIn
|
ubiquitous
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gptkbp:fullName
|
gptkb:Eukaryotic_translation_initiation_factor_4E-binding_protein_1
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gptkbp:function
|
inhibits cap-dependent translation initiation
regulates translation by binding to eIF4E
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gptkbp:gene
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gptkb:EIF4EBP1
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gptkbp:GO
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GO:0006417 (regulation of translation)
GO:0005852 (eukaryotic translation initiation factor 4F complex)
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gptkbp:HGNC_ID
|
gptkb:HGNC:3288
|
https://www.w3.org/2000/01/rdf-schema#label
|
EIF4EBP1
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gptkbp:interactsWith
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gptkb:eIF4E
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gptkbp:locatedOnChromosome
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gptkb:8p12
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gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
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gptkbp:molecularWeight
|
13 kDa
|
gptkbp:OMIM
|
601293
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
gptkbp:orthologIn
|
mouse Eif4ebp1
rat Eif4ebp1
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
|
gptkbp:PDB
|
1WKW
|
gptkbp:phosphorylates
|
Ser65
Thr37
Thr46
Thr70
regulates its activity
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
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gptkbp:proteinFamily
|
eIF4E-binding protein family
|
gptkbp:RefSeq
|
gptkb:NM_004095
|
gptkbp:regulates
|
dephosphorylated by PP2A
phosphorylated by mTORC1
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
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gptkbp:sequence
|
118 amino acids
|
gptkbp:structure
|
intrinsically disordered protein
|
gptkbp:subfamily
|
eIF4E-binding proteins
|
gptkbp:tissue_specificity
|
widely expressed
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gptkbp:UniProtID
|
gptkb:Q13541
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gptkbp:bfsParent
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gptkb:4EBP1
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gptkbp:bfsLayer
|
6
|