EIF4EBP1

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alias EIF4EBP-1
eIF-4E-binding protein 1
gptkbp:alternativeName gptkb:4E-BP1
gptkb:PHAS-I
gptkbp:associatedWith gptkb:cancer
metabolic disorders
EIF4EBP2
EIF4EBP3
gptkbp:Entrez_Gene_ID gptkb:ENSG00000187840
1978
gptkbp:expressedIn ubiquitous
gptkbp:fullName gptkb:Eukaryotic_translation_initiation_factor_4E-binding_protein_1
gptkbp:function inhibits cap-dependent translation initiation
regulates translation by binding to eIF4E
gptkbp:gene gptkb:EIF4EBP1
gptkbp:GO GO:0006417 (regulation of translation)
GO:0005852 (eukaryotic translation initiation factor 4F complex)
gptkbp:HGNC_ID gptkb:HGNC:3288
https://www.w3.org/2000/01/rdf-schema#label EIF4EBP1
gptkbp:interactsWith gptkb:eIF4E
gptkbp:locatedOnChromosome gptkb:8p12
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight 13 kDa
gptkbp:OMIM 601293
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn mouse Eif4ebp1
rat Eif4ebp1
gptkbp:pathway gptkb:mTOR_signaling_pathway
gptkbp:PDB 1WKW
gptkbp:phosphorylates Ser65
Thr37
Thr46
Thr70
regulates its activity
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:proteinFamily eIF4E-binding protein family
gptkbp:RefSeq gptkb:NM_004095
gptkbp:regulates dephosphorylated by PP2A
phosphorylated by mTORC1
gptkbp:reviewedBy gptkb:UniProtKB/Swiss-Prot
gptkbp:sequence 118 amino acids
gptkbp:structure intrinsically disordered protein
gptkbp:subfamily eIF4E-binding proteins
gptkbp:tissue_specificity widely expressed
gptkbp:UniProtID gptkb:Q13541
gptkbp:bfsParent gptkb:4EBP1
gptkbp:bfsLayer 6