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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alias
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EIF4EBP-1
eIF-4E-binding protein 1
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gptkbp:alternativeName
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gptkb:4E-BP1
gptkb:PHAS-I
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gptkbp:associatedWith
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gptkb:cancer
metabolic disorders
EIF4EBP2
EIF4EBP3
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000187840
1978
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gptkbp:expressedIn
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ubiquitous
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gptkbp:fullName
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gptkb:Eukaryotic_translation_initiation_factor_4E-binding_protein_1
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gptkbp:function
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inhibits cap-dependent translation initiation
regulates translation by binding to eIF4E
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gptkbp:gene
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gptkb:EIF4EBP1
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gptkbp:GO
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GO:0006417 (regulation of translation)
GO:0005852 (eukaryotic translation initiation factor 4F complex)
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gptkbp:HGNC_ID
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gptkb:HGNC:3288
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gptkbp:interactsWith
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gptkb:eIF4E
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gptkbp:locatedOnChromosome
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gptkb:8p12
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gptkbp:location
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:molecularWeight
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13 kDa
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gptkbp:OMIM
|
601293
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
|
mouse Eif4ebp1
rat Eif4ebp1
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gptkbp:pathway
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gptkb:mTOR_signaling_pathway
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gptkbp:PDB
|
1WKW
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gptkbp:phosphorylates
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Ser65
Thr37
Thr46
Thr70
regulates its activity
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gptkbp:postTranslationalModification
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phosphorylation
ubiquitination
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gptkbp:proteinFamily
|
eIF4E-binding protein family
|
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gptkbp:RefSeq
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gptkb:NM_004095
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gptkbp:regulates
|
dephosphorylated by PP2A
phosphorylated by mTORC1
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gptkbp:reviewedBy
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gptkb:UniProtKB/Swiss-Prot
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gptkbp:sequence
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118 amino acids
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gptkbp:structure
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intrinsically disordered protein
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gptkbp:subfamily
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eIF4E-binding proteins
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gptkbp:tissue_specificity
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widely expressed
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gptkbp:UniProtID
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gptkb:Q13541
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gptkbp:bfsParent
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gptkb:4E-BP1
gptkb:4EBP1
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gptkbp:bfsLayer
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7
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https://www.w3.org/2000/01/rdf-schema#label
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EIF4EBP1
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