|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:KIAA0131
ARHGEF31
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
glioma
|
|
gptkbp:biologicalProcess
|
regulation of cell cycle
regulation of cell shape
Rho guanyl-nucleotide exchange factor activity
|
|
gptkbp:discoveredBy
|
Tatsuo Sekido et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:Entrez_Gene_ID
|
1894
ENSG00000163597
|
|
gptkbp:expressedIn
|
high in proliferating cells
upregulated in several cancers
|
|
gptkbp:fullName
|
gptkb:Epithelial_cell_transforming_sequence_2_oncogene
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:gene
|
gptkb:ECT2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:3152
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ECT2
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:RhoA
gptkb:Cdk1
gptkb:Rac1
|
|
gptkbp:involvedIn
|
cell division
cytokinesis
|
|
gptkbp:length
|
883 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
3q26.31
|
|
gptkbp:molecularWeight
|
97 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenic transformation
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:overexpressedIn
|
linked to tumorigenesis
|
|
gptkbp:phosphorylates
|
yes
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
RhoGEF family
|
|
gptkbp:significance
|
biomarker for cancer prognosis
|
|
gptkbp:structure
|
contains BRCT domains
contains Dbl homology (DH) domain
contains Pleckstrin homology (PH) domain
|
|
gptkbp:subcellularLocation
|
midbody during cytokinesis
|
|
gptkbp:UniProtID
|
Q9H8V3
|
|
gptkbp:bfsParent
|
gptkb:Ect2
|
|
gptkbp:bfsLayer
|
7
|