|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:E6-AP
gptkb:E6-associated_protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:autism_spectrum_disorder
gptkb:Angelman_syndrome
|
|
gptkbp:biologicalProcess
|
protein ubiquitination
|
|
gptkbp:containsGene
|
gptkb:UBE3A
|
|
gptkbp:domain
|
gptkb:HECT_domain
|
|
gptkbp:encodedBy
|
gptkb:UBE3A_gene
|
|
gptkbp:enzymeCommissionNumber
|
EC 6.3.2.-
|
|
gptkbp:expressedIn
|
gptkb:testis
brain
various tissues
|
|
gptkbp:function
|
ubiquitin-protein ligase activity
|
|
gptkbp:hasMutationAssociatedWith
|
gptkb:Angelman_syndrome
|
|
gptkbp:hasRole
|
cell cycle regulation
protein degradation
neurodevelopment
synaptic function
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
E6AP ubiquitin ligase
|
|
gptkbp:involvedIn
|
ubiquitin-dependent protein catabolic process
protein modification by small protein conjugation
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:partOf
|
ubiquitin-proteasome system
|
|
gptkbp:PDB
|
1C4Z
|
|
gptkbp:target
|
gptkb:HPV_E6_protein
|
|
gptkbp:UniProtID
|
gptkb:Q05086
|
|
gptkbp:bfsParent
|
gptkb:E6_protein_of_HPV
|
|
gptkbp:bfsLayer
|
8
|