Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:virus
|
| gptkbp:contributedTo |
cellular immortalization
|
| gptkbp:encodedBy |
gptkb:E6_gene
|
| gptkbp:firstDescribed |
1980s
|
| gptkbp:foundIn |
gptkb:human_papillomavirus
|
| gptkbp:function |
oncoprotein
|
| https://www.w3.org/2000/01/rdf-schema#label |
E6 protein of HPV
|
| gptkbp:inhibitedBy |
apoptosis
|
| gptkbp:interactsWith |
gptkb:p53_protein
gptkb:E6AP_ubiquitin_ligase gptkb:PDZ_domain-containing_proteins |
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
approximately 18 kDa
|
| gptkbp:presentIn |
gptkb:HPV16
gptkb:HPV18 gptkb:high-risk_HPV_types |
| gptkbp:promotion |
degradation of p53
|
| gptkbp:role |
gptkb:cancer
|
| gptkbp:sequence |
151 amino acids (HPV16 E6)
|
| gptkbp:structure |
contains zinc finger motifs
|
| gptkbp:bfsParent |
gptkb:UBE3A
|
| gptkbp:bfsLayer |
7
|